Marko Lehtonen Selected Research

LY2881835

11/2016

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

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Marko Lehtonen Research Topics

Disease

7	Neoplasms (Cancer) 11/2023 - 04/2010
6	Type 2 Diabetes Mellitus (MODY) 02/2024 - 11/2016
4	Obesity 10/2023 - 11/2013
4	Insulin Resistance 10/2023 - 11/2017
4	Pain (Aches) 04/2023 - 06/2008
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023 - 01/2015
4	Inflammation (Inflammations) 12/2022 - 01/2018
3	Glioma (Gliomas) 12/2023 - 01/2015
3	Breast Neoplasms (Breast Cancer) 11/2023 - 10/2016
3	Alcoholism (Alcohol Abuse) 11/2021 - 10/2009
2	Parkinson Disease (Parkinson's Disease) 05/2024 - 01/2020
2	Fatty Liver 10/2023 - 01/2023
2	Non-alcoholic Fatty Liver Disease 10/2023 - 01/2023
2	Body Weight (Weight, Body) 01/2023 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 01/2022
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2022 - 01/2005
2	Opioid-Related Disorders (Opiate Addiction) 11/2022 - 01/2021
2	Postoperative Pain 02/2018 - 04/2008
2	Schizophrenia (Dementia Praecox) 01/2017 - 08/2013
2	Nervous System Diseases (Neurological Disorders) 10/2016 - 12/2011
2	Cataract (Cataracts) 01/2007 - 09/2006
1	Glioblastoma (Glioblastoma Multiforme) 12/2023
1	Brain Neoplasms (Brain Tumor) 12/2023
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2023
1	Osteoarthritis 12/2023
1	Migraine Disorders (Migraine) 04/2023
1	Liver Diseases (Liver Disease) 01/2023
1	Weight Loss (Weight Reduction) 01/2023
1	Dyslipidemias (Dyslipidemia) 01/2023
1	Neuroinflammatory Diseases 12/2022
1	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2022
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2022
1	Hypoxia (Hypoxemia) 10/2021
1	Overweight 02/2021

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 11/2023 - 03/2013
8	LipidsIBA 10/2023 - 03/2013
5	Biomarkers (Surrogate Marker)IBA 02/2024 - 09/2016
4	ProdrugsIBA 12/2023 - 10/2016
4	Buprenorphine (Subutex)FDA LinkGeneric 12/2023 - 01/2021
4	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 01/2015
4	Fatty Acids (Saturated Fatty Acids)IBA 10/2023 - 01/2011
4	EndocannabinoidsIBA 04/2023 - 10/2009
3	Caffeine (No Doz)FDA LinkGeneric 05/2024 - 02/2021
3	EnzymesIBA 01/2023 - 01/2020
2	Dopamine (Intropin)FDA LinkGeneric 05/2024 - 01/2017
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 12/2023 - 11/2023
2	A-Form DNA (A-DNA)IBA 12/2023 - 07/2021
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2023 - 09/2016
2	ProteomeIBA 12/2022 - 03/2013
2	Ganciclovir (Cytovene)FDA LinkGeneric 07/2021 - 01/2015
2	Insulin (Novolin)FDA Link 01/2021 - 11/2019
2	Analgesics (Analgesic Drugs)IBA 02/2018 - 04/2008
2	Tryptophan (L-Tryptophan)FDA Link 01/2018 - 09/2016
2	indolepropionic acidIBA 01/2018 - 11/2017
2	Tamsulosin (Flomax)FDA LinkGeneric 01/2007 - 09/2006
1	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 05/2024
1	Coffee FDA Link 05/2024
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 05/2024
1	Alkylating AgentsIBA 12/2023
1	Temozolomide (Temodar)FDA LinkGeneric 12/2023
1	Hormones (Hormone)IBA 11/2023
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2023
1	palbociclibIBA 11/2023
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2023
1	human ERBB2 proteinIBA 11/2023
1	GlycogenIBA 10/2023
1	Alanine Transaminase (SGPT)IBA 10/2023
1	Pregnane X ReceptorIBA 10/2023
1	anandamide (arachidonylethanolamide)IBA 04/2023
1	glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA 04/2023
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 04/2023
1	Monoacylglycerol LipasesIBA 04/2023
1	Histidine (L-Histidine)FDA Link 01/2023
1	Metformin (Glucophage)FDA LinkGeneric 01/2023
1	Testosterone (Sustanon)FDA Link 01/2023
1	Glycerophospholipids (Phosphoglycerides)IBA 01/2023
1	nicotinamide-beta-ribosideIBA 01/2023
1	NAD (NADH)IBA 01/2023
1	Lysine (L-Lysine)FDA Link 01/2023
1	LipopolysaccharidesIBA 12/2022
1	diazonaphthalenedisulfonic acid (NDS)IBA 12/2022
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/2022
1	Pyruvic Acid (Pyruvate)IBA 01/2022
1	CreatineIBA 01/2022
1	fibroblast growth factor 21IBA 01/2022
1	Growth Differentiation Factor 15IBA 01/2022
1	Succinic Acid (Succinate)IBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	GhrelinIBA 11/2021
1	triphosphoric acid (triphosphate)IBA 07/2021
1	Adenosine Triphosphate (ATP)IBA 07/2021
1	Methotrexate (Mexate)FDA LinkGeneric 07/2021
1	C-Reactive ProteinIBA 01/2021
1	Amino Acids FDA Link 01/2021

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 12/2023 - 07/2021
2	Analgesia 02/2018 - 10/2016
1	Transdermal Patch 12/2023
1	Anesthesia 10/2021
1	Therapeutics 07/2021
1	Chemoprevention 01/2020